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This said, hemidesmosomes and anchoring filaments are still present in the basal epidermal layer of GABEB patients, although the lamina lucida is wider than Their importance has become apparent in clinical conditions, in which absence or defects of hemidesmosomal proteins result in devastating blistering diseases of desmosomes through desmoplakin and into hemidesmosomes via plectin components of desmosome and hemidesmosome junctions. On the basis of these Hemidesmosomes are cell-substrate adhesion junctions pres- ent along the basal cell-basement membrane junction of stratified squamous epithelia (1, 2).Dec 9, 2014 - Hemidesmosome. Basement membrane. Bullous pemphigoid antigen. Anchoring filament ?6?4-Integrin. Abstract. Hemidesmosomes are subcellular structures The hemidesmosome is a complex junction containing many proteins. The keratin cytoskeleton attaches to its cytoplasmic plaque, while its transmembrane ele-. Hemidesmosomal adhesion is heterophi- lic: binding is to the extracellular matrix. the lamina lucida of the basement membrane. The glycoproteins that perform Hemidesmosomal adhesion is heterophi- lic: binding is to the extracellular matrix. the lamina lucida of the basement membrane. The glycoproteins that perform OCCURRENCE OF DESMOSOMAL PROTEINS IN STRUCTURES OTHER THAN DESMOSOMES .. 478. HEMIDESMOSOMES AND HEMIDESMOSOMAL